Anesthesia and analgesia.
Publisher:
International Anesthesia Research Society.. Baltimore, Md. : Lippincott Williams & Wilkins (1998)
Frequency: Monthly
Country: United States
Language: English
Author(s):
International Anesthesia Research Society.
Start Year:1957 -
Identifiers
| ISSN: | 0003-2999 (Print) 1526-7598 (Electronic) 0003-2999 (Linking) |
| NLM ID: | 1310650 |
| (DNLM): | A30330000(s) |
| (OCoLC): | 01481131 |
| Coden: | AACRAT |
| LCCN: | 2004265703 |
| Classification: | W1 AN218 |
The pharmacokinetics of hemoglobin-based oxygen carrier hemoglobin glutamer-200 bovine in the horse. Hemoglobin-glutamer-200 (HBOC-200) is a hemoglobin (Hb)-based oxygen carrier (HBOC) comprising glutaraldehyde-polymerized bovine Hb. In this study, we sought to determine the pharmacokinetics of this first generation HBOC after IV infusion of 32.5 g of HBOC-200 solution in horses. Quantification of HBOC-200 in equine plasma and urine was performed using a method recently developed by our laboratory. The elimination from plasma was based on size distribution of the bovine Hb polymer. The decline of plasma concentration-time curve of HBOC-200 was described by a noninterchanging 2-compartmental m...
Nitrous oxide: effect on accumulation rate and uptake of bowel gases. Breathing 79% nitrous oxide (N2O) in oxygen increased the rate of accumulation of bowel gas during intraluminal bowel segment infusions of hydrogen, methane (CH4), air, or carbon dioxide (CO2) in four pentobarbital-anesthetized dogs more than did breathing 100% oxygen. A N2O-associated increase in the volume of naturally produced intestinal gas in five halothane-anesthetized ponies corroborated the findings in the dog studies. In a second group of four dogs a bolus of CH4 or CO2 was injected into the bowel lumen. When the dogs breathed O2 the bowel gas volume decreased. Gas was virtually absen...