Arthritis.
Discontinued
Publisher:
Hindawi Pub. Corp.
Frequency: Irregular
Country: United States
Language: English
Start Year:2010 - 2018
ISSN:
2090-1992 (Electronic)
2090-1984 (Print)
2090-1992 (Linking)
2090-1984 (Print)
2090-1992 (Linking)
Impact Factor
1
| NLM ID: | 101566207 |
| (OCoLC): | 740815216 |
| LCCN: | 2011243726 |
Inflammation and immune response of intra-articular serotype 2 adeno-associated virus or adenovirus vectors in a large animal model. Intra-articular gene therapy has potential for the treatment of osteoarthritis and rheumatoid arthritis. To quantify in vitro relative gene transduction, equine chondrocytes and synovial cells were treated with adenovirus vectors (Ad), serotype 2 adeno-associated virus vectors (rAAV2), or self-complementary (sc) AAV2 vectors carrying green fluorescent protein (GFP). Using 6 horses, bilateral metacarpophalangeal joints were injected with Ad, rAAV2, or scAAV2 vectors carrying GFP genes to assess the in vivo joint inflammation and neutralizing antibody (NAb) titer in serum and joint fluid. In vit...