Arzneimittel-Forschung.
Discontinued
Publisher:
Editio Cantor
Frequency: Monthly
Country: Germany
Language: ger
Start Year:1951 - 2012
Identifiers
| ISSN: | 0004-4172 (Print) 1616-7066 (Electronic) 0004-4172 (Linking) |
| NLM ID: | 0372660 |
| (OCoLC): | 01514393 |
| (DNLM): | A68700000(s) |
| Coden: | ARZNAD |
| LCCN: | 87645332 $z 55001432 |
| Classification: | W1 AR966 |
Activity of coagulation and fibrinolysis parameters in animals. Using diagnostics for the determination of clotting factors and fibrinolytic parameters in human plasma, samples from rat, guinea pig, rabbit, cat, dog, sheep, cattle, horse, pig, and monkey were analysed. The human system was employed even for standard curves and controls. Results obtained in this way are relative values in relation to pooled fresh human plasma of healthy donors which is defined to contain 100% of the norm or 1 unit of each factor per 1 ml. Under these conditions, marked differences between the human clotting system and those of different animal species appear. Thus, rabbits ...
Immunological safety evaluation of a haemostatic agent and wound dressing made of horse collagen fibrils. A haemostatic agent and wound dressing made of horse collagen (Tachotop) was applied to guinea-pigs in such a way that the intended use of this material in humans was simulated, and cell-mediated and humoral immune responses of the animals were investigated. In addition, immune reactions were forcefully induced in guinea-pigs in order to validate the methodical approach and quantitate the observed reactions. Cell-mediated immunity was measured as delayed-type hypersensitivity skin reactions, and antibodies were detected by an enzyme-linked immunosorbent assay (ELISA). Simulation of the intende...