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Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
Discontinued
Publisher:
Kluge Carden Jennings Publishing, Co., Ltd.,. Charlottesville, VA : Carden Jennings Publishing
Frequency: 10 no. a year,
Country: United States
Language: English
Author(s):
American Society for Blood and Marrow Transplantation.
Start Year:1995 - 2020
Identifiers
| ISSN: | 1083-8791 (Print) 1523-6536 (Electronic) 1083-8791 (Linking) |
| NLM ID: | 9600628 |
| (DNLM): | SR0083281(s) |
| (OCoLC): | 32904974 |
| Coden: | BBMTF6 |
| LCCN: | sn 95005881 |
| Classification: | W1 BI852JM |
Different outcomes between cyclophosphamide plus horse or rabbit antithymocyte globulin for HLA-identical sibling bone marrow transplant in severe aplastic anemia. The standard regimen for HLA-identical sibling bone marrow transplant (BMT) in severe aplastic anemia (SAA) is cyclophosphamide (Cy) and horse antithymocyte globulin (ATG). Horse ATG has been replaced by rabbit ATG in many countries due to the unavailability of the former product. This study was designed to assess if these ATG preparations are interchangeable in the preparative regimen for matched related BMT in SAA. Forty consecutive BMTs were retrospectively analyzed: 20 received Cy plus horse ATG and 20 received Cy plus rabbit ATG as the preparative regimen. Conditioning with rabbit ATG was...
Heterogeneous clearance of antithymocyte globulin after CD34+-selected allogeneic hematopoietic progenitor cell transplantation. Antithymocyte globulins (ATG) are purified, concentrated preparations of polyclonal immunoglobulin G from hyperimmune serum of horses or rabbits immunized with human thymus lymphocytes. Both the horse and the rabbit products induce immunosuppression as a result of lymphocyte depletion and immune modulation. The exact mechanism of action is unknown but may include T-cell clearance from the circulation and modulation of T-cell activation, homing, and cytotoxic activities. Both horse and rabbit ATG include multiple antibodies against T-cell surface antigens and have been used extensively in allog...
