BMC cancer.
Publisher:
BioMed Central,
Country: England
Language: English
Start Year:2001 -
ISSN:
1471-2407 (Electronic)
1471-2407 (Linking)
1471-2407 (Linking)
Impact Factor
3.8
2022
| NLM ID: | 100967800 |
| (OCoLC): | 45893944 |
| Coden: | BCMACL |
| LCCN: | 2002243079 |
Constitutive activation of the ERK pathway in melanoma and skin melanocytes in Grey horses. Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings. The Grey phenotype in horses, caused by a 4.6 kb duplication in intron 6 of Syntaxin 17 (STX17), is associated with a very high incidence of cutaneous melanoma, but the molecular mechanism behind the melanomagenesis remains unknown. Here, we investigated the involvement of the ERK pathway in melanoma development in Grey horses. Methods: Grey horse melanoma tumours, cell lines ...