British journal of clinical pharmacology.
Publisher:
Macmillan Journals Ltd.. Oxford : Wiley-Blackwell
Frequency: Monthly
Country: England
Language: English
Author(s):
British Pharmacological Society.
Start Year:1974 -
ISSN:
0306-5251 (Print)
1365-2125 (Electronic)
0306-5251 (Linking)
1365-2125 (Electronic)
0306-5251 (Linking)
Impact Factor
3.4
2023
| NLM ID: | 7503323 |
| (DNLM): | B34520000(s) |
| (OCoLC): | 01266516 |
| Coden: | BCPHBM |
| LCCN: | sn 81001432 |
| Classification: | W1 BR519RI |
Bronchopulmonary pharmacokinetics of (R)-salbutamol and (S)-salbutamol enantiomers in pulmonary epithelial lining fluid and lung tissue of horses. Salbutamol is usually administered as a racemic mixture but little is known about the enantioselectivity of salbutamol pharmacokinetics in the lung. This study was designed to investigate enantiomer concentrations in lung tissue after inhaled dosing. Horses (n = 12) received racemic salbutamol 1000 μg via inhalation. Enantioselective ultra performance liquid chromatography-tandem mass spectrometry was used to determine salbutamol concentrations in pulmonary epithelial lining fluid (PELF) sampled 2, 5, 10 and 15 min after administration, in central lung (endoscopic bronchial biopsy) and per...