Chemical & pharmaceutical bulletin.
Publisher:
Pharmaceutical Society of Japan.
Frequency: Monthly
Country: Japan
Language: English
Author(s):
Nihon Yakugakkai.
Start Year:1958 -
ISSN:
0009-2363 (Print)
1347-5223 (Electronic)
0009-2363 (Linking)
1347-5223 (Electronic)
0009-2363 (Linking)
Impact Factor
1.7
2022
| NLM ID: | 0377775 |
| (DNLM): | C15520000(s) |
| (OCoLC): | 06067231 |
| Coden: | CPBTAL |
| LCCN: | 62051273 |
| Classification: | W1 CH245N |
Pharmacokinetics of caffeine and its metabolites in horses after intravenous, intramuscular or oral administration. The pharmacokinetics of caffeine (CAF) and its metabolites, dimethylxanthines, were examined in horses administered 2.5 mg/kg of CAF intravenously (i.v.), intramusculary (i.m.), or orally (p.o.). The plasma samples were extracted by Extrelut and the concentrations of CAF and metabolites were determined by high performance liquid chromatography (HPLC) with a short column. The pharmacokinetics of CAF after bolus i.v. injection were described by the assumption of a two-compartment model, and those of CAF after i.m. or p.o. administration were done by the assumption of a one-compartment model. The...
Detection and identification of loline and its analogues in horse urine. Several kinds of loline-type alkaloids, norloline, loline, N-acetylnorloline, N-acetylloline, N-formylnorloline, N-formylloline and N-methylloline were detected in the urine of race-horses. Furthermore, a new compound of the alkaloids, N-senecioylnorloline, was also found and identified. These compounds were mainly identified by means of gas chromatography-mass spectrometry (GC-MS) and gas chromatography-fourier transform-infrared spectrometry (GC-FT-IR). A certain plant of Gramineae containing four kinds of loline-type alkaloids was found in a bale of hay used for the horse forage. The taxono...