Clinical and experimental pharmacology & physiology.
Publisher:
Blackwell Scientific Publications.. Oxford, England : Wiley-Blackwell
Frequency: Monthly
Country: Australia
Language: English
Start Year:1974 -
ISSN:
0305-1870 (Print)
1440-1681 (Electronic)
0305-1870 (Linking)
1440-1681 (Electronic)
0305-1870 (Linking)
Impact Factor
2.9
2022
| NLM ID: | 0425076 |
| (DNLM): | C25540000(s) |
| (OCoLC): | 00972372 |
| Coden: | CEXPB9 |
| Classification: | W1 CL664E |
Anti-remodelling drugs for the treatment of asthma: requirement for animal models of airway wall remodelling. 1. Airway wall remodelling (AWR), the structural change induced by acute and chronic inflammation in the airways, may be one of the most significant and difficult to reverse components of progressive asthma. 2. The mechanisms underlying the development of AWR are not known. Studies of only the most superficial wall structures of large airways can be conducted in living humans because of the degree of invasiveness required to measure airway structural changes. These studies reveal that currently available agents do not fully prevent or reverse AWR. Thus, animal models of asthma pathology may be...
Equine angiotensin converting enzyme: a zinc metalloenzyme. 1. Angiotensin I converting enzyme from horse plasma has been extensively purified and shown to be homogeneous by disc-gel electrophoresis. 2. The metal ion involved in the catalytic reaction of the enzyme has been identified for the first time as zinc by atomic absorption spectrometry. 3. A number of other physicochemical properties of the enzyme are described and compared with results obtained by other investigators. The molecular weight was determined by gel filtration to be 113 000 daltons. The pH maximum was found to be 7-4. The chloride activation of the enzyme appears to act by facilita...