Current HIV research.
Publisher:
Bentham Science Publishers,
Frequency: Six issues per year, 2014-
Country: Netherlands
Language: English
Start Year:2003 -
ISSN:
1570-162X (Print)
1873-4251 (Electronic)
1570-162X (Linking)
1873-4251 (Electronic)
1570-162X (Linking)
Impact Factor
1
| NLM ID: | 101156990 |
| (OCoLC): | 52384296 |
| LCCN: | 2003243274 |
| Classification: | W1 CU788JBC |
Molecular and biological characterization of equine infectious anemia virus Rev. Equine infectious anemia virus (EIAV) is one of the most divergent members of the lentivirus subfamily of retroviruses and is considered a useful comparative model for molecular studies of lentivirus replication. The Rev protein of EIAV is functionally homologous with other lentiviral Revs and facilitates export of incompletely spliced viral mRNAs through a Crm1-dependent pathway. The trans- and cis-acting elements that mediate EIAV Rev function are similar to, but distinct from, the well-characterized elements in human immunodeficiency virus (HIV-1), the prototypical Rev protein. In addition,...
Virulence determinants of equine infectious anemia virus. Equine infectious anemia virus (EIAV) is a macrophage-tropic lentivirus that rapidly Induces disease in experimentally infected horses. Because EIAV infection and replication is centered on the monocyte/macrophage and has a pronounced acute disease stage, it is a useful model system for understanding the contribution of monocyte/macrophages to other lentivirus-induced diseases. Genetic mapping studies utilizing chimeric proviruses in which parental viruses are acutely virulent or avirulent have allowed the identification of important regions that influence acute virulence. U3 regions in the vi...