Drug delivery and translational research.
Publisher:
Springer
Frequency: Bimonthly
Country: United States
Language: English
Author(s):
Controlled Release Society.
Start Year:2011 -
ISSN:
2190-393X (Print)
2190-3948 (Electronic)
2190-393X (Linking)
2190-3948 (Electronic)
2190-393X (Linking)
Impact Factor
5.4
2022
| NLM ID: | 101540061 |
| (OCoLC): | 750403667 |
| LCCN: | 2011208482 |
| Classification: | W1 DR514BH |
Intra-articular delivery of a nanocomplex comprising salmon calcitonin, hyaluronic acid, and chitosan using an equine model of joint inflammation. Polyelectrolyte nanoparticle constructs (NPs) comprising salmon calcitonin (sCT), chitosan (CS), and hyaluronic acid (HA) were previously established as having anti-inflammatory potential when injected via the intra-articular (i.a.) route to a mouse model. We attempted to translate the formulation to a large animal model, the lipopolysaccharide (LPS)-stimulated equine model of joint inflammation. The aim was to manufacture under aseptic conditions to produce sterile pyrogen-free NPs, to confirm physicochemical characteristics, and to test toxicity and efficacy in a pilot study. NP dispersions ...