Drug development and industrial pharmacy.
Publisher:
Dekker.. London : Informa Healthcare
Frequency: Annual, 2014-
Country: England
Language: English
Start Year:1977 -
ISSN:
0363-9045 (Print)
1520-5762 (Electronic)
0363-9045 (Linking)
1520-5762 (Electronic)
0363-9045 (Linking)
Impact Factor
3.4
2022
| NLM ID: | 7802620 |
| (DNLM): | D20620000(s) |
| (OCoLC): | 02855103 |
| Coden: | DDIPD8 |
| LCCN: | 77648300 |
| Classification: | W1 DR521BL |
Intra-articular injection of morphine to the horse: establishment of an in vitro-in vivo relationship. In the area of parenteral depots, a strong need exists for the development of suitable in vitro drug release models that might enable establishment of in vitro-in vivo relations (IVIVRs). Objective: The objective of this study was to investigate the possibility of establishing an IVIVR between morphine disappearance from the joint cavity and in vitro release data obtained employing the rotating dialysis cell model. Methods: In vitro release experiments were conducted using the rotating dialysis cell model. For establishment of an IVIVR, data from a previous study on pharmacokinetics of intra-a...