Environmental pollution.
Publisher:
Elsevier Applied Science Publishers,
Frequency: Fifteen no. a year, 2001
Country: England
Language: English
Start Year:1987 -
ISSN:
0269-7491 (Print)
1873-6424 (Electronic)
0269-7491 (Linking)
1873-6424 (Electronic)
0269-7491 (Linking)
Impact Factor
8.9
2022
| NLM ID: | 8804476 |
| (DNLM): | SR0059680(s) |
| (OCoLC): | 15211864 |
| Coden: | ENPOEK |
| LCCN: | 92648929 |
| Classification: | W1 EN984XFA |
Structural and functional analysis of the inhibition of equine glutathione transferase A3-3 by organotin endocrine disrupting pollutants. Organotin compounds are highly toxic environmental pollutants with neurotoxic and endocrine-disrupting effects. They are potent inhibitors of glutathione transferases (GSTs), thus impeding their detoxication and antioxidant functions. Several GSTs, including equine GST A3-3 (EcaGST A3-3), exhibit steroid double-bond isomerase activity and are involved in the biosynthesis of testosterone and progesterone. We have performed enzyme kinetics analyses of the inhibition of EcaGST A3-3 by organotin compounds. We have also solved crystal structures of EcaGST A3-3 in complexes with glutathione, and wit...
Chloride/bromide ratios in leachate derived from farm-animal waste. Ratios of conservative chemicals have been used to identify sources of groundwater contamination. While chloride/bromide ratios have been reported for several common sources of groundwater contamination, little work has been done on leachate derived from farm-animal waste. In this study, chloride/bromide ratios were measured in leachate derived from longhorn-cattle, quarterhorse, and pygme-goat waste at a farm in Abilene, Texas, USA. (Minimum, median, and maximum) chloride/bromide ratios of (66.5, 85.6, and 167), (119, 146, and 156), and (35.4, 57.8, and 165) were observed for cattle, horses, ...