Epigenetics & chromatin.
Publisher:
BioMed Central
Country: England
Language: English
Start Year:2008 -
ISSN:
1756-8935 (Electronic)
1756-8935 (Linking)
1756-8935 (Linking)
Impact Factor
3.9
2022
| NLM ID: | 101471619 |
| (OCoLC): | 263688252 |
| LCCN: | 2008247801 |
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI. Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmetric between the paternal and the maternal genome. The paternal genome undergoes ten-eleven translocation (TET)-mediated active DNA demethylation, which is completed before the end of the first cell cycle. Since TET enzymes oxidize 5-methylcytosine to 5-hydroxymethylcytosine, the latter is postulated to be an intermediate stage toward DNA demethylation. The maternal genome, on the other ha...