European journal of drug metabolism and pharmacokinetics.
Publisher:
Edifor.. Paris : Springer France (2010)
Frequency: Quarterly
Country: France
Language: English
Start Year:1976 -
ISSN:
0378-7966 (Print)
2107-0180 (Electronic)
0378-7966 (Linking)
2107-0180 (Electronic)
0378-7966 (Linking)
Impact Factor
1.9
2022
| NLM ID: | 7608491 |
| (DNLM): | E16080000(s) |
| (OCoLC): | 02181264 |
| Coden: | EJDPD2 |
| Classification: | W1 EU72DD |
Identification of detomidine carboxylic acid as the major urinary metabolite of detomidine in the horse. Horse urine was investigated for metabolites by chromatography and mass spectrometry following the oral administration of the large animal analgesic sedative detomidine to two stallions and intravenous administration of [3H]-detomidine to a mare. Detomidine carboxylic acid and hydroxydetomidine glucuronic acid conjugate were identified in the urine after the oral doses. In addition, traces of free hydroxydetomidine were observed. About half of the radioactivity of [3H]-detomidine was excreted in the urine in 12 h after the i.v. dose (80 micrograms/kg). Most of the excretion occurred between 5 ...