FASEB bioAdvances.
Publisher:
John Wiley & Sons, Inc.,
Frequency: Twelve issues a year
Country: United States
Language: English
Author(s):
Federation of American Societies for Experimental Biology,
Start Year:2018 -
ISSN:
2573-9832 (Electronic)
2573-9832 (Linking)
2573-9832 (Linking)
Impact Factor
2.7
2023
| NLM ID: | 101733210 |
| (OCoLC): | 994870912 |
| LCCN: | 2017202855 |
| Classification: | W1 |
The effects of oxidative stress and intracellular calcium on mitochondrial permeability transition pore formation in equine spermatozoa. The in vitro storage of stallion spermatozoa for use in artificial insemination leads to oxidative stress and imbalances in calcium homeostasis that trigger the formation of the mitochondrial permeability transition pore (mPTP), resulting in premature cell death. However, little is understood about the dynamics and the role of mPTP formation in mammalian spermatozoa. Here, we identify an important role for mPTP in stallion sperm Ca2+ homeostasis. We show that stallion spermatozoa do not exhibit "classical" features of mPTP; specifically, they are resistant to cyclosporin A-mediated inhibition...
Dynamic regulation of the transcriptome and proteome of the equine embryo during maternal recognition of pregnancy. During initial maternal recognition of pregnancy (MRP), the equine embryo displays a series of unique events characterized by rapid blastocyst expansion, secretion of a diverse array of molecules, and transuterine migration to interact with the uterine surface. Up to date, the intricate transcriptome and proteome changes of the embryo underlying these events have not been critically studied in horses. Thus, the objective of this study was to perform an integrative transcriptomic (including mRNA, miRNAs, and other small non-coding RNAs) and proteomic analysis of embryos collected from days 10 t...