Fundamental and applied toxicology : official journal of the Society of Toxicology.
Discontinued
Publisher:
The Society,. Orlando Fl : Academic Press
Frequency: Twelve no. a year
Country: United States
Language: English
Author(s):
Society of Toxicology (U.S.)
Start Year:1981 - 1997
ISSN:
0272-0590 (Print)
0272-0590 (Linking)
0272-0590 (Linking)
Impact Factor
3.8
| NLM ID: | 8200838 |
| (DNLM): | F15030000(s) |
| (OCoLC): | 06753527 |
| Coden: | FAATD |
| Classification: | W1 FU538M |
Species dependent gentamicin pharmacokinetics and nephrotoxicity in the young horse. Gentamicin pharmacokinetics and nephrotoxic potential were evaluated in twelve 2 to 3 month-old horses. Whereas recent evidence in our clinic indicated that young horses may be especially susceptible to gentamicin nephrotoxicity, young rabbits and rats are usually resistant. Gentamicin (4.5 mg/kg) was given by rapid intravenous injection. Serum gentamicin concentrations over a 13-hour period were fitted to an open, two-compartment, pharmacokinetic model. Subsequently, the same horses were divided into groups of 3 horses each. Each group received 0, 2.2, 4.4 or 8.8 mg gentamicin/kg, intramuscul...