Genes and immunity.
Publisher:
Nature Pub. Group,
Frequency: Eight no. a year, 2001-
Country: England
Language: English
Start Year:199u -
ISSN:
1466-4879 (Print)
1476-5470 (Electronic)
1466-4879 (Linking)
1476-5470 (Electronic)
1466-4879 (Linking)
Impact Factor
5
2022
| NLM ID: | 100953417 |
| (OCoLC): | 44773925 |
| LCCN: | 00-243396 |
| Classification: | W1 GE274D |
IgE-binding monocytes upregulate the coagulation cascade in allergic horses. IgE-binding monocytes are a rare peripheral immune cell type involved in the allergic response through binding of IgE on their surface. IgE-binding monocytes are present in both healthy and allergic individuals. We performed RNA sequencing to ask how the function of IgE-binding monocytes differs in the context of allergy. Using a large animal model of allergy, equine Culicoides hypersensitivity, we compared the transcriptome of IgE-binding monocytes in allergic and non-allergic horses at two seasonal timepoints: (i) when allergic animals were clinical healthy, in the winter "Remission Phase", ...
MHC haplotype diversity in Icelandic horses determined by polymorphic microsatellites. The Icelandic horse has been maintained as a closed population in its eponymous homeland for many generations, with no recorded introductions of new horses of any breed since the year 1000 CE. Here we determined the diversity of major histocompatibility complex (MHC) haplotypes in 156 Icelandic horses from two groups, based on a panel of 12 polymorphic intra-MHC microsatellites tested in families of various composition. We identified a total of 79 MHC haplotypes in these two groups, including one documented intra-MHC recombination event from a total of 147 observed meioses. None of these MHC h...