Human gene therapy methods.
Discontinued
Publisher:
Mary Ann Liebert
Frequency: Bimonthly
Country: United States
Language: English
Author(s):
European Society of Gene and Cell Therapy.
Start Year:2011 - 2019
ISSN:
1946-6536 (Print)
1946-6544 (Electronic)
1946-6536 (Linking)
1946-6544 (Electronic)
1946-6536 (Linking)
Impact Factor
4.2
2022
| NLM ID: | 101573202 |
| (OCoLC): | 301215437 |
| LCCN: | 2009202175 |
| Classification: | W1 HU448BB |
Development of an equine-tropic replication-competent lentivirus assay for equine infectious anemia virus-based lentiviral vectors. The release of lentiviral vectors for clinical use requires the testing of vector material, production cells, and, if applicable, ex vivo-transduced cells for the presence of replication-competent lentivirus (RCL). Vectors derived from the nonprimate lentivirus equine infectious anemia virus (EIAV) have been directly administered to patients in several clinical trials, with no toxicity observed to date. Because EIAV does not replicate in human cells, and because putative RCLs derived from vector components within human vector production cells would most likely be human cell-tropic, we previous...