International journal of cardiology. Heart & vasculature.
Publisher:
Elsevier Ireland Ltd.,
Country: Ireland
Language: English
Start Year:2014 -
ISSN:
2352-9067 (Electronic)
2352-9067 (Linking)
2352-9067 (Linking)
Impact Factor
2.9
2022
| NLM ID: | 101649525 |
| (OCoLC): | 895357658 |
| LCCN: | 2015243384 |
| Classification: | W1 |
Increased fibroblast accumulation in the equine heart following persistent atrial fibrillation. Fibroblasts maintain the extracellular matrix homeostasis and may couple to cardiomyocytes through gap junctions and thereby increase the susceptibility to slow conduction and cardiac arrhythmias, such as atrial fibrillation (AF). In this study, we used an equine model of persistent AF to characterize structural changes and the role of fibroblasts in the development of an arrhythmogenic substrate for AF. Methods: Eleven horses were subjected to atrial tachypacing until self-sustained AF developed and were kept in AF for six weeks. Horses in sinus rhythm (SR) served as control. In terminal open...