Journal of cellular and molecular medicine.
Publisher:
"Carol Davila" University Press,. Oxford, England : Wiley-Blackwell
Frequency: Quarterly
Country: England
Language: English
Start Year:2000 -
ISSN:
1582-1838 (Print)
1582-4934 (Electronic)
1582-1838 (Linking)
1582-4934 (Electronic)
1582-1838 (Linking)
Impact Factor
5.3
2023
| NLM ID: | 101083777 |
| (OCoLC): | 46362607 |
| Coden: | JCMMC9 |
| LCCN: | 2001243053 |
| Classification: | W1 JO7575 |
Combination of resveratrol and 5-azacytydine improves osteogenesis of metabolic syndrome mesenchymal stem cells. Endocrine disorders have become more and more frequently diagnosed in humans and animals. In horses, equine metabolic syndrome (EMS) is characterized by insulin resistance, hyperleptinemia, hyperinsulinemia, inflammation and usually by pathological obesity. Due to an increased inflammatory response in the adipose tissue, cytophysiological properties of adipose derived stem cells (ASC) have been impaired, which strongly limits their therapeutic potential. Excessive accumulation of reactive oxygen species, mitochondria deterioration and accelerated ageing of those cells affect their multipotency...
Equine metabolic syndrome impairs adipose stem cells osteogenic differentiation by predominance of autophagy over selective mitophagy. Adipose-derived mesenchymal stem cells (ASC) hold great promise in the treatment of many disorders including musculoskeletal system, cardiovascular and/or endocrine diseases. However, the cytophysiological condition of cells, used for engraftment seems to be fundamental factor that might determine the effectiveness of clinical therapy. In this study we investigated growth kinetics, senescence, accumulation of oxidative stress factors, mitochondrial biogenesis, autophagy and osteogenic differentiation potential of ASC isolated from horses suffered from equine metabolic syndrome (EMS). We demons...