Journal of controlled release : official journal of the Controlled Release Society.
Publisher:
Elsevier Science Publishers,
Frequency: Twenty four no. a year, 2001-
Country: Netherlands
Language: English
Author(s):
Controlled Release Society.
Start Year:1984 -
ISSN:
0168-3659 (Print)
1873-4995 (Electronic)
0168-3659 (Linking)
1873-4995 (Electronic)
0168-3659 (Linking)
Impact Factor
10.8
2022
| NLM ID: | 8607908 |
| (DNLM): | J17975000(s) |
| (OCoLC): | 11301964 |
| Coden: | JCREEC |
| Classification: | W1 JO596C |
Controlled nail delivery of a novel lipophilic antifungal agent using various modern drug carrier systems as well as in vitro and ex vivo model systems. The penetration behavior into human nails and animal hoof membranes of a novel antifungal agent (EV-086K) for the treatment of onychomycosis was investigated in this study. The new drug provides a high lipophilicity which is adverse for penetration into nails. Therefore, four different formulations were developed, with particular focus on a colloidal carrier system (CCS) due to its penetration enhancing properties. On the one hand, ex vivo penetration experiments on human nails were performed. Afterwards the human nail plates were cut by cryomicrotome in order to quantify the drug concentratio...