Journal of developmental origins of health and disease.
Publisher:
Cambridge University Press,
Frequency: Bimonthly
Country: England
Language: English
Author(s):
International Society for Developmental Origins of Health and Disease.
Start Year:2010 -
ISSN:
2040-1744 (Print)
2040-1752 (Electronic)
2040-1744 (Linking)
2040-1752 (Electronic)
2040-1744 (Linking)
Impact Factor
1.7
2022
| NLM ID: | 101517692 |
| (OCoLC): | 503445665 |
| LCCN: | 2010210977 |
| Classification: | W1 JO619U |
Neonatal glucocorticoid overexposure alters cardiovascular function in young adult horses in a sex-linked manner. Prenatal glucocorticoid overexposure has been shown to programme adult cardiovascular function in a range of species, but much less is known about the long-term effects of neonatal glucocorticoid overexposure. In horses, prenatal maturation of the hypothalamus-pituitary-adrenal axis and the normal prepartum surge in fetal cortisol occur late in gestation compared to other precocious species. Cortisol levels continue to rise in the hours after birth of full-term foals and increase further in the subsequent days in premature, dysmature and maladapted foals. Thus, this study examined the adult ca...
Effects of birth weight, sex and neonatal glucocorticoid overexposure on glucose-insulin dynamics in young adult horses. In several species, adult metabolic phenotype is influenced by the intrauterine environment, often in a sex-linked manner. In horses, there is also a window of susceptibility to programming immediately after birth but whether adult glucose-insulin dynamics are altered by neonatal conditions remains unknown. Thus, this study investigated the effects of birth weight, sex and neonatal glucocorticoid overexposure on glucose-insulin dynamics of young adult horses. For the first 5 days after birth, term foals were treated with saline as a control or ACTH to raise cortisol levels to those of stressed...