Journal of endotoxin research.
Discontinued
Publisher:
Churchill Livingstone,. Los Angeles : Sage Publications
Frequency: Six no. a year, 1995-
Country: United States
Language: English
Author(s):
International Endotoxin Society., International Endotoxin & Innate Immunity Society.
Start Year:1994 - 2007
ISSN:
0968-0519 (Print)
1743-2839 (Electronic)
0968-0519 (Linking)
1743-2839 (Electronic)
0968-0519 (Linking)
Impact Factor
3.2
2022
| NLM ID: | 9433350 |
| (DNLM): | SR0078937(s) |
| (OCoLC): | 30775970 |
| Coden: | JENREB |
| LCCN: | sn 94038642 |
| Classification: | W1 JO643F |
The equine TLR4/MD-2 complex mediates recognition of lipopolysaccharide from Rhodobacter sphaeroides as an agonist. Lipopolysaccharide (LPS) antagonists inhibit the response of inflammatory cells to LPS, presumably by competitive inhibition, and may be of therapeutic value in the treatment of endotoxemia and sepsis. The inhibitory effects of some LPS antagonists are restricted to certain host species, however, as the same molecules can have significant endotoxic activity in other species. This species-specific recognition appears to be mediated by Toll-like receptor 4 (TLR4) and/or MD-2. We have shown previously that LPS from Rhodobacter sphaeroides ( RsLPS) is an LPS antagonist in human cells but an agonis...
Lipopolysaccharide from Rhodobacter sphaeroides is an agonist in equine cells. Endotoxemia is associated with the principal causes of death in adult horses and equine neonates and, therefore, veterinary researchers are expending efforts to identify new therapeutic interventions that might be beneficial in these animals. Endotoxin antagonists inhibit interaction of endotoxin with cellular receptors and may be beneficial in the treatment of endotoxemia and sepsis. Diphosphoryl lipid A from Rhodobacter sphaeroides (RsDPLA) is a potent antagonist of enteric LPS in human cells, but is an agonist in hamster cells. In this study, the effect of lipopolysaccharide from R. sphaero...