Journal of enzyme inhibition.
Discontinued
Publisher:
G+B/Harwood,. Chur : Harwood Academic
Frequency: 6 no. a year, 1998-
Country: Switzerland
Language: English
Start Year:1985 - 2001
ISSN:
8755-5093 (Print)
1026-5457 (Linking)
1026-5457 (Linking)
Impact Factor
| NLM ID: | 8709734 |
| (DNLM): | SR0055474(s) |
| (OCoLC): | 11332414 |
| Coden: | ENINEG |
| LCCN: | sn 84001720 |
| Classification: | W1 JO644BN |
Inhibition and inactivation of equine aromatase by steroidal and non-steroidal compounds. A comparison with human aromatase inhibition. In order to approach the detailed structure-function relationships of aromatase, we studied the inhibitory and inactivatory potencies of several steroidal androstenedione analogues (1: 4-hydroxyandrostenedione, 2: 4-acetoxyandrostenedione and 3: 7 alpha-(4'-amino)phenylthio-4-androstene-3, 17-dione) and non-steroidal imidazole derivatives (4: ketoconazole, 5: miconazole and 6: fadrozole) on equine aromatase in placental microsomes, a well established mammalian model. Human placental microsomes and the purified enzyme from equine testis were also used to compare inhibition by 1 and 2. In equine...