Journal of experimental orthopaedics.
Publisher:
Springer
Frequency: One issue per year, 2014-
Country: Germany
Language: English
Author(s):
European Society of Sports Traumatology, Knee Surgery and Arthroscopy,
Start Year:2014 -
ISSN:
2197-1153 (Electronic)
2197-1153 (Linking)
2197-1153 (Linking)
Impact Factor
1.8
2022
| NLM ID: | 101653750 |
| (OCoLC): | 884467041 |
| LCCN: | 2014254718 |
The benefits and limitations of animal models for translational research in cartilage repair. Much research is currently ongoing into new therapies for cartilage defect repair with new biomaterials frequently appearing which purport to have significant regenerative capacity. These biomaterials may be classified as medical devices, and as such must undergo rigorous testing before they are implanted in humans. A large part of this testing involves in vitro trials and biomechanical testing. However, in order to bridge the gap between the lab and the clinic, in vivo preclinical trials are required, and usually demanded by regulatory approval bodies. This review examines the in vivo models ...
What quantitative mechanical loading stimulates in vitro cultivation best? Articular cartilage has limited regeneration capacities. One of the factors that appear to affect the in vitro cultivation of articular cartilage is mechanical stimulation. So far, no combination of parameters has been identified that offers the best results. The goal is to review the literature in search of the best available set of quantitative mechanical stimuli that lead to optimal in vitro cultivation.The databases Scopus and PubMed were used to survey the literature, and strict in- and exclusion criteria were applied regarding the presence of quantitative data. The review was performed b...