Journal of immunotherapy.
Publisher:
Lippincott-Raven,. Hagerstown, MD : Lippincott Williams & Wilkins
Frequency: Nine no. a year, 2008-
Country: United States
Language: English
Author(s):
Society for Biological Therapy.
Start Year:1997 -
Identifiers
| ISSN: | 1524-9557 (Print) 1537-4513 (Electronic) 1524-9557 (Linking) |
| NLM ID: | 9706083 |
| (DNLM): | SR0090916(s) |
| (OCoLC): | 36596495 |
| Coden: | JOIMF8 |
| LCCN: | sn 97039179 |
| Classification: | W1 JO679G |
Double-blind placebo-controlled study with interleukin-18 and interleukin-12-encoding plasmid DNA shows antitumor effect in metastatic melanoma in gray horses. Melanoma is a disease with high incidence in gray horses and has limited therapeutic options in metastatic disease. Gene therapy has shown some success in animal models and human patients. A randomized double-blind, placebo-controlled study was conducted to investigate 2 treatment options using cytokine-encoding plasmid DNA in horses with metastatic melanoma to induce immunologic antitumor effects. Adult gray horses with spontaneously occurring metastatic melanoma (n=26) were included in the study. Treatment of 26 gray horses with metastatic melanoma consisted of interleukin-18-encoding plasmi...