Journal for immunotherapy of cancer.
Publisher:
BioMed Central,. London, United Kingdom : BMJ Publishing Group Ltd. (2020)
Country: England
Language: English
Author(s):
Society for Immunotherapy of Cancer,
Start Year:2013 -
ISSN:
2051-1426 (Electronic)
2051-1426 (Linking)
2051-1426 (Linking)
Impact Factor
10.9
2022
| NLM ID: | 101620585 |
| (OCoLC): | 846867215 |
| LCCN: | 2013254548 |
Simple and effective bacterial-based intratumoral cancer immunotherapy. We describe intratumoral injection of a slow-release emulsion of killed mycobacteria (complete Freund's adjuvant (CFA)) in three preclinical species and in human cancer patients. Efficacy and safety were tested in mammary tumors in mice, in mastocytomas in mice and dogs, and in equine melanomas. In mice, survival, tumor growth, and tumor infiltration by six immune cell subsets (by flow cytometry) were investigated and analyzed using Cox proportional hazards, a random slopes model, and a full factorial model, respectively. Tumor growth and histology were investigated in dogs and horses, as well...