Journal of insect science.
Publisher:
University of Arizona Library,. Annapolis, MD : Entomological Society of America
Country: United States
Language: English
Author(s):
Entomological Society of America.
Start Year:2001 -
ISSN:
1536-2442 (Electronic)
1536-2442 (Linking)
1536-2442 (Linking)
Impact Factor
2.2
2022
| NLM ID: | 101096396 |
| (OCoLC): | 46820266 |
| Coden: | JISTCY |
| LCCN: | 2001220164 |
Practical uses for ecdysteroids in mammals including humans: an update. Ecdysteroids are widely used as inducers for gene-switch systems based on insect ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements. We review here these systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies. Such developments raise several questions, which are addressed in detail. First, the metabolic fate of ecdysteroids in mammals, including humans, is only poorly known, and the rapid catabo...