Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
Publisher:
Mary Ann Liebert,. Larchmont, NY : Mary Ann Liebert
Frequency: Monthly
Country: United States
Language: English
Author(s):
International Society for Interferon and Cytokine Research.
Start Year:1995 -
ISSN:
1079-9907 (Print)
1557-7465 (Electronic)
1079-9907 (Linking)
1557-7465 (Electronic)
1079-9907 (Linking)
Impact Factor
2.3
2022
| NLM ID: | 9507088 |
| (DNLM): | SR0083220(s) |
| (OCoLC): | 31698749 |
| Coden: | JICRFJ |
| Classification: | W1 JO716KM |
Anti-Influenza A Virus Activities of Type I/III Interferons-Induced Mx1 GTPases from Different Mammalian Species. Type I/III interferons provide powerful and universal innate intracellular defense mechanisms against viruses. Among the antiviral effectors induced, Mx proteins of some species appear as key components of defense against influenza A viruses. It is expected that such an antiviral protein must display a platform dedicated to the recognition of said viruses. In an attempt to identify such platform in human MxA, an evolution-guided approach capitalizing on the antagonistic arms race between MxA and its viral targets and the genomic signature it left on primate genomes revealed that the surface-ex...
Genomic analysis and mRNA expression of equine type I interferon genes. This study aimed at identifying all of the type I interferon (IFN) genes of the horse and at monitoring their expression in equine cells on in vitro induction. We identified 32 putative type I IFN loci on horse chromosome 23 and an unplaced genomic scaffold. A phylogentic analysis characterized these into 8 different type I IFN classes, that is, putative functional genes for 6 IFN-α, 4 IFN-β, 8 IFN-ω (plus 4 pseudogenes), 3 IFN-δ (plus 1 pseudogene), 1 IFN-κ and 1 IFN-ε, plus 1 IFN-ν pseudogene, and 3 loci belonging to what has previously been called IFN-αω. Our analyses indicate that...