Journal of neurophysiology.
Publisher:
American Physiological Society. Bethesda Md : American Physiological Society
Frequency: Monthly, 2016-
Country: United States
Language: English
Author(s):
American Physiological Society (1887- )
Start Year:1938 -
ISSN:
0022-3077 (Print)
1522-1598 (Electronic)
0022-3077 (Linking)
1522-1598 (Electronic)
0022-3077 (Linking)
Impact Factor
2.5
2022
| NLM ID: | 0375404 |
| (DNLM): | J31120000(s) |
| (OCoLC): | 01695642 |
| Coden: | JONEA4 |
| LCCN: | 41016569 |
| Classification: | W1 JO794 |
Sodium channel inactivation is impaired in equine hyperkalemic periodic paralysis. 1. Equine hyperkalemic periodic paralysis (E-HPP) is a dominantly inherited disorder of muscle that causes recurrent episodes of stiffness (myotonia) and weakness in association with elevated serum K+. Affected horses carry a mutant allele of the skeletal muscle isoform of the Na channel alpha-subunit. To understand how this mutation may cause the disease phenotype, the functional defect in Na channel behavior was defined physiologically by recording unitary currents from cell-attached patches on normal and affected equine myotubes. 2. The presence of the mutation was confirmed in our cell lin...