The Journal of pathology.
Publisher:
Oliver & Boyd.. Chichester : John Wiley And Sons
Frequency: Monthly
Country: England
Language: English
Author(s):
Pathological Society of Great Britain and Ireland.
Start Year:1969 -
ISSN:
0022-3417 (Print)
1096-9896 (Electronic)
0022-3417 (Linking)
1096-9896 (Electronic)
0022-3417 (Linking)
Impact Factor
7.3
2022
| NLM ID: | 0204634 |
| (DNLM): | J33880000(s) |
| (OCoLC): | 01754718 |
| Coden: | JPTLAS |
| LCCN: | sn 80001300 |
| Classification: | W1 JO828B |
Spontaneously occurring melanoma in animals and their relevance to human melanoma. In contrast to other cancer types, melanoma incidence has been increasing over the last 50 years, and while it still represents less than 5% of all cutaneous malignancies, melanoma accounts for the majority of skin cancer deaths, due to its propensity to metastasise. Whilst melanoma most commonly affects the skin, it can also arise in mucosal surfaces, the eye, and the brain. For new therapies to be developed, a better understanding of the genetic landscape, signalling pathways, and tumour-microenvironmental interactions is needed. This is where animal models are of critical importance. The ...
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse. The hepatotoxic effect of oral halothane in the horse is increased by pretreatment with phenobarbitone or DDT but not by chlorpromazine. Phenobarbitone and DDT increase the activity of hepatic amidopyrine N-demethylase but chlorpromazine does not. Carbon disulphide protects the liver of the horse against halothane.
Haemorrhagic nasal polyps of the horse. A series of 10 haemorrhagic polyps of the equine nasal cavity is described. The lesions show haematoma formation, abundant haemosiderin in macrophages and giant cells, and organising fibrous tissue. In one case, angiomatoid lesions were observed in the mucous membrane of the paranasal sinuses and it is suggested that some haemorrhagic nasal polyps may originate from pre-existing haemangiomatous areas in the respiratory mucosa.