Journal of xenobiotics.
Publisher:
PAGEPress,. [Basel, Switzerland] : MDPI AG (2020)
Country: Switzerland
Language: English
Start Year:2011 -
ISSN:
2039-4713 (Electronic)
2039-4705 (Print)
2039-4705 (Linking)
2039-4705 (Print)
2039-4705 (Linking)
Impact Factor
6
| NLM ID: | 101701430 |
| (OCoLC): | 823686945 |
| LCCN: | 2013265010 |
| Classification: | W1 |
Nanoformulation of a Trypanocidal Drug Isometamidium Chloride Ameliorates the Apurinic-Apyrimidinic DNA Sites/Genotoxic Effects in Horse Blood Cells. Isometamidium chloride (ISM) is a trypanocide for the prophylactic and therapeutic use against vector-borne animal trypanosomosis (mainly Surra caused by ) and African animal trypanosomosis caused by //). ISM was found to be an efficient trypanocide for therapeutic/prophylactic use against trypanosomosis; however, it produces some local and systemic detrimental effects in animals. We synthesized isometamidium chloride-loaded alginate gum acacia nanoformulation (ISM SANPS) to lessen the detrimental side effects of isometamidium chloride (ISM) while treating trypanosomal diseases. We intended to...