Kidney & blood pressure research.
Publisher:
Karger,
Frequency: Six no. a year
Country: Switzerland
Language: English
Author(s):
Gesellschaft für Nephrologie., Deutsche Liga zur Bekämpfung des hohen Blutdrucks., Deutsche Hypertonie Gesellschaft.
Start Year:1996 -
ISSN:
1420-4096 (Print)
1423-0143 (Electronic)
1420-4096 (Linking)
1423-0143 (Electronic)
1420-4096 (Linking)
Impact Factor
2.8
| NLM ID: | 9610505 |
| (DNLM): | SR0088451(s) |
| (OCoLC): | 35073635 |
| Coden: | KBPRFC |
| Classification: | W1 RE198G |
Evaluation of KIM-1 and NGAL as Early Indicators for Assessment of Gentamycin-Induced Nephrotoxicity In Vivo and In Vitro. The aminolycoside Gentamicin is a widely used antibiotic, applied in equine medicine. Despite its clinical use, concerns remain regarding the potential toxic side-effects, such as nephrotoxicity. Early detection of renal damage is critical in preclinical drug development. This study was aimed to determine whether kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) may be early indicators in the assessment of Gentamycin-induced nephrotoxicity. Methods: In our study, a model of Gentamicin-induced nephrotoxicity in male Sprague Dawley rats treated for up to 7 da...