The Lancet. Global health.
Publisher:
Elsevier Ltd.
Frequency: Monthly
Country: England
Language: English
Start Year:2013 -
ISSN:
2214-109X (Electronic)
2214-109X (Linking)
2214-109X (Linking)
Impact Factor
34.3
2022
| NLM ID: | 101613665 |
| (OCoLC): | 832424997 |
| LCCN: | 2013250652 |
Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2 × 2 factorial randomised controlled trial. Intramuscular antitoxin is recommended in tetanus treatment, but there are few data comparing human and equine preparations. Tetanus toxin acts within the CNS, where there is limited penetration of peripherally administered antitoxin; thus, intrathecal antitoxin administration might improve clinical outcomes compared with intramuscular injection. In a 2 × 2 factorial trial, all patients aged 16 years or older with a clinical diagnosis of generalised tetanus admitted to the intensive care unit of the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, were eligible for study entr...