Lymphatic research and biology.
Publisher:
Mary Ann Liebert, Inc.,
Frequency: Bimonthly, 2018-
Country: United States
Language: English
Author(s):
Lymphatic Research Foundation.
Start Year:2003 -
ISSN:
1539-6851 (Print)
1557-8585 (Electronic)
1539-6851 (Linking)
1557-8585 (Electronic)
1539-6851 (Linking)
Impact Factor
1.4
2022
| NLM ID: | 101163587 |
| (OCoLC): | 49608838 |
| LCCN: | 2002213520 |
| Classification: | W1 LY52 |
Measurement of skin desmosine as an indicator of altered cutaneous elastin in draft horses with chronic progressive lymphedema. Chronic progressive lymphedema in Clydesdale and Shire draft horses causes severe disability of the limbs which leads to premature death of these horses. Since appropriate function of lymph vessels is dependent on the presence of viable elastin fibers, the goal of this study was to document differences in skin elastin fibers in affected horse breeds, compared to a nonaffected draft horse breed. Results: Biochemical analysis of cutaneous desmosine, a cross-linking amino acid found only in elastin, was used to measure elastin in the skin from 110 draft horses. This included 7 normal, 38 mildly a...
Progressive swelling, hyperkeratosis, and fibrosis of distal limbs in Clydesdales, Shires, and Belgian draft horses, suggestive of primary lymphedema. A condition characterized by progressive swelling, hyperkeratosis, and fibrosis of the distal limbs has been recognized in Shire, Clydesdale, and Belgian draft horses. This chronic progressive disease starts at an early age, progresses throughout the life of the horse, and often ends in disfigurement and disability of the limbs that inevitably leads to the horse's premature death. This study was undertaken to better characterize this disease. Results: Six affected horses were donated for diagnostic workup. A detailed clinical, radiologic, gross, and histologic description is given in this repo...