Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
Materials today. Bio.
Publisher:
Elsevier Ltd.,
Frequency: Quarterly
Country: England
Language: English
Start Year:2019 -
ISSN:
2590-0064 (Electronic)
2590-0064 (Linking)
2590-0064 (Linking)
Impact Factor
8.2
2022
| NLM ID: | 101757228 |
| (OCoLC): | 1100534654 |
| LCCN: | 2020243116 |
| Classification: | W1 |
Cell-permeable bone morphogenetic protein 2 facilitates bone regeneration by promoting osteogenesis. The use of the FDA-approved osteoinductive growth factor BMP2 is widespread for bone regeneration. However, its clinical application has been hindered by limitations in cell permeability and a short half-life in circulation. To address this issue, we have developed a modified version of BMP2, referred to as Cell Permeable (CP)-BMP2, which possesses improved cell permeability. CP-BMP2 incorporates an advanced macromolecular transduction domain (aMTD) to facilitate transfer across the plasma membrane, a solubilization domain, and recombinant human BMP2. Compared to traditional rhBMP2, CP-BMP2 ex...
Microfluidic nutrient gradient-based three-dimensional chondrocyte culture-on-a-chip as an in vitro equine arthritis model. In this work, we describe a microfluidic three-dimensional (3D) chondrocyte culture mimicking in vivo articular chondrocyte morphology, cell distribution, metabolism, and gene expression. This has been accomplished by establishing a physiologic nutrient diffusion gradient across the simulated matrix, while geometric design constraints of the microchambers drive native-like cellular behavior. Primary equine chondrocytes remained viable for the extended culture time of 3 weeks and maintained the low metabolic activity and high Sox9, aggrecan, and Col2 expression typical of articular chondrocytes...
