Omneity® Pellets
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Mechanisms of development.
Discontinued
Publisher:
Elsevier Scientific Publishers Ireland,. Limerick : Elsevier
Frequency: Twenty-four no. a year 2003-
Country: Ireland
Language: English
Start Year:1990 - 2020
Identifiers
| ISSN: | 0925-4773 (Print) 1872-6356 (Electronic) 0925-4773 (Linking) |
| NLM ID: | 9101218 |
| (DNLM): | SR0069279(s) |
| (OCoLC): | 22927690 |
| Coden: | MEDVE6 |
| LCCN: | 92645804 |
| Classification: | W1 ME106AG |
The transcription factor scleraxis differentially regulates gene expression in tenocytes isolated at different developmental stages. The transcription factor scleraxis (SCX) is expressed throughout tendon development and plays a key role in directing tendon wound healing. However, little is known regarding its role in fetal or young postnatal tendons, stages in development that are known for their enhanced regenerative capabilities. Here we used RNA-sequencing to compare the transcriptome of adult and fetal tenocytes following SCX knockdown. SCX knockdown had a larger effect on gene expression in fetal tenocytes, affecting 477 genes in comparison to the 183 genes affected in adult tenocytes, indicating that scleraxis-depend...
