Molecular pharmacology.
Publisher:
American Society for Pharmacology and Experimental Therapeutics
Frequency: Monthly
Country: United States
Language: English
Author(s):
American Society for Pharmacology and Experimental Therapeutics.
Start Year:1965 -
ISSN:
0026-895X (Print)
1521-0111 (Electronic)
0026-895X (Linking)
1521-0111 (Electronic)
0026-895X (Linking)
Impact Factor
4.054
2021
| NLM ID: | 0035623 |
| (DNLM): | M43360000(s) |
| (OCoLC): | 01680861 |
| Coden: | MOPMA3 |
| LCCN: | 65009928 |
| Classification: | W1 MO197 |
Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases. To understand the role of glycosylation in the circulation of cholinesterases, we compared the mean residence time of five tissue-derived and two recombinant cholinesterases (injected intravenously in mice) with their oligosaccharide profiles. Monosaccharide composition analysis revealed differences in the total carbohydrate, galactose, and sialic acid contents. The molar ratio of sialic acid to galactose residues on tetrameric human serum butyrylcholinesterase, recombinant human butyrylcholinesterase, and recombinant mouse acetylcholinesterase was found to be approximately 1.0. For Torpedo ca...
Cross-species comparison of 5-lipoxygenase-activating protein. To identify regions of 5-lipoxygenase-activating protein (FLAP) important for the function of the protein and the binding of leukotriene biosynthesis inhibitors, we performed a cross-species analysis of FLAP. FLAP from all 10 mammalian species analyzed (human, monkey, horse, pig, cow, sheep, rabbit, dog, rat, and mouse) were immunologically cross-reactive and specifically bound leukotriene biosynthesis inhibitors with high affinity. Using the polymerase chain reaction, cDNA clones for FLAP from six species (monkey, horse, pig, sheep, rabbit, and mouse) were isolated and sequenced. The deduced ...