Mucosal immunology.
Publisher:
Nature Pub. Group,. [New York, NY] : Elsevier (2023)
Frequency: Bimonthly
Country: United States
Language: English
Author(s):
Society for Mucosal Immunology.
Start Year:2008 -
ISSN:
1933-0219 (Print)
1935-3456 (Electronic)
1933-0219 (Linking)
1935-3456 (Electronic)
1933-0219 (Linking)
Impact Factor
8
2022
| NLM ID: | 101299742 |
| (OCoLC): | 71052494 |
| LCCN: | 2006214376 |
| Classification: | W1 MU343 |
IgA in the horse: cloning of equine polymeric Ig receptor and J chain and characterization of recombinant forms of equine IgA. As in other mammals, immunoglobulin A (IgA) in the horse has a key role in immune defense. To better dissect equine IgA function, we isolated complementary DNA (cDNA) clones for equine J chain and polymeric Ig receptor (pIgR). When coexpressed with equine IgA, equine J chain promoted efficient IgA polymerization. A truncated version of equine pIgR, equivalent to secretory component, bound with nanomolar affinity to recombinant equine and human dimeric IgA but not with monomeric IgA from either species. Searches of the equine genome localized equine J chain and pIgR to chromosomes 3 and 5, resp...