Naunyn-Schmiedeberg's archives of pharmacology.
Publisher:
Springer Verlag.
Frequency: Monthly
Country: Germany
Language: English
Author(s):
Deutsche Pharmakologische Gesellschaft.
Start Year:1972 -
ISSN:
0028-1298 (Print)
1432-1912 (Electronic)
0028-1298 (Linking)
1432-1912 (Electronic)
0028-1298 (Linking)
Impact Factor
3.6
2022
| NLM ID: | 0326264 |
| (DNLM): | N09920000(s) |
| (OCoLC): | 01771667 |
| Coden: | NSAPCC |
| Classification: | W1 NA987 |
Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals. Macrolide antibiotics penetrate in the lung against steep concentration gradients into the epithelial lining fluid (ELF) and broncho-alveolar cells (BAC). Since they interact with ABCB1, ABCC2, and organic anion transporting proteins (OATPs), which are localized to lung tissue, pulmonary concentration may be influenced by rifampicin (RIF), an inducer and modulator of efflux and uptake transporters. We measured concentrations of tulathromycin (TM) in plasma, ELF and BAC in 21 warm-blooded foals 24 and 192 h after first and last intramuscular injection of 2.5 mg/kg TM once weekly for 6 weeks. In...