Neurobiology of disease.
Publisher:
Blackwell Science,. San Diego, CA : Academic Press
Frequency: Monthly, 2013-
Country: United States
Language: English
Start Year:1994 -
ISSN:
0969-9961 (Print)
1095-953X (Electronic)
0969-9961 (Linking)
1095-953X (Electronic)
0969-9961 (Linking)
Impact Factor
6.1
2022
| NLM ID: | 9500169 |
| (DNLM): | SR0078925(s) |
| (OCoLC): | 31828108 |
| Coden: | NUDIEM |
| Classification: | W1 NE323SM |
D159 and S167 are protective residues in the prion protein from dog and horse, two prion-resistant animals. Prion diseases are fatal neurodegenerative diseases caused by misfolding of the prion protein (PrP). These conditions affect humans and animals, including endemic forms in sheep and deer. Bovine, rodents, and many zoo mammals also developed prion diseases during the "mad-cow" epidemic in the 1980's. Interestingly, rabbits, horses, and dogs show unusual resistance to prion diseases, suggesting that specific sequence changes in the corresponding endogenous PrP prevents the accumulation of pathogenic conformations. In vitro misfolding assays and structural studies have identified S174, S167, and ...