Neurogastroenterology and motility.
Publisher:
Blackwell Scientific Publications,
Frequency: Bimonthly, 1998-
Country: England
Language: English
Author(s):
European Gastrointestinal Motility Society., American Neurogastroenterology and Motility Society., Functional Brain-Gut Research Group.
Start Year:1994 -
ISSN:
1350-1925 (Print)
1365-2982 (Electronic)
1350-1925 (Linking)
1365-2982 (Electronic)
1350-1925 (Linking)
Impact Factor
3.96
| NLM ID: | 9432572 |
| (DNLM): | SR0080990(s) |
| (OCoLC): | 30130557 |
| Coden: | NMOTEK |
| Classification: | W1 NE328GB |
Localization of the 5-hydroxytryptamine 4 receptor in equine enteric neurons and extrinsic sensory fibers. Serotonin plays a pivotal role in regulating gut motility, visceral sensitivity, and fluid secretion via specific receptors. Among these receptors, 5-HT exerts a prominent control on gut motor function. Although the prokinetic effect exerted by 5-HT agonists is well known, the cellular sites of 5-HT expression remain poorly understood in large mammals, e.g., horses. In this study, we evaluated the distribution of 5-HT in the horse intestine and in foals with enteric aganglionosis, reminiscent of human Hirschsprung's disease. Methods: The intestine and spinal ganglia were obtained from three he...
The neurology and enterology of equine grass sickness: a review of basic mechanisms. Autonomic dysfunction constitutes a prominent clinical feature of equine grass sickness (EGS). Significant injury to the nervous control of the alimentary system is life threatening, partly because of dysphagia but also because of the failure of the unique regulatory mechanisms in equine digestion involving water and electrolyte balance. The neuropathology also indicates the presence of a somatic polyneuropathy. The morphological features of EGS are similar to those of excitotoxic neuronal degeneration, which resembles neuronal apoptosis. It is difficult to ascertain from published accounts th...