Novartis Foundation symposium.
Discontinued
Publisher:
Wiley
Frequency: Irregular
Country: England
Language: English
Author(s):
Novartis Foundation for Gerontological Research.
Start Year:1998 - 2008
Identifiers
| ISSN: | 1528-2511 (Print) 1935-4657 (Electronic) 1528-2511 (Linking) |
| NLM ID: | 9807767 |
| (DNLM): | SR0093180(s) |
| (OCoLC): | 38995697 |
| LCCN: | sn 98040947 |
| Classification: | W1 NO9285 |
The role of apoptotic regulators in metaplastic mucous cells. Exposure of airways to environmental toxins or allergens induces proliferation of epithelial cells. Depending on the type of exposure, existing and newly formed cells can differentiate into mucus-producing cells resulting in mucous cell metaplasia (MCM). During recovery, the epithelium reduces the number of epithelial cells to return to the original state. Understanding the mechanisms involved in this resolution could be useful in deleting mucous cells and, thereby, mucous secretions. We have found that metaplastic mucous cells induced by exposure to ozone, endotoxin, cigarette smoke or allerg...