Pediatric pharmacology.
Discontinued
Publisher:
Alan R. Liss,
Frequency: Four no. a year
Country: United States
Language: English
Start Year:1980 - 1986
Identifiers
| ISSN: | 0270-322X (Print) 0270-322X (Linking) |
| NLM ID: | 8400778 |
| (DNLM): | P06430000(s) |
| (OCoLC): | 06389346 |
| Coden: | PPHAD4 |
| Classification: | W1 PE17H |
The effect of benzo(a)pyrene on fertility, primordial oocyte number, and ovarian response to pregnant mare’s serum gonadotropin. The polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene (BP) reduced the fertility of DBA/2N mice in a dose-dependent fashion. Control mice produced offspring at a rate of 0.91 pups/mouse per week. Treatment with BP at doses of 10, 100, 200, and 500 mg/kg decreased offspring production rates to 0.61, 0.20, zero and zero pups/mouse per week, respectively. BP also destroyed primordial oocytes in similarly treated mice. Treatment with BP at doses of 10, 50, 100, and 500 mg/kg destroyed 20%, 58%, 88%, and 100%, respectively, of the primordial oocytes in DBA/2N mouse ovaries. Dose-response curves ...