Pharmacology.
Publisher:
Karger,
Frequency: Twelve no. a year, 2002-
Country: Switzerland
Language: English
Start Year:1968 -
ISSN:
0031-7012 (Print)
1423-0313 (Electronic)
0031-7012 (Linking)
1423-0313 (Electronic)
0031-7012 (Linking)
Impact Factor
3.1
| NLM ID: | 0152016 |
| (DNLM): | P11280000(s) |
| (OCoLC): | 01597962 |
| Coden: | PHMGBN |
| Classification: | W1 PH283 |
Segment-dependent activation of muscarinic acetylcholine receptor-mediated [35S]Guanosine-5′-O-(gamma-thiotriphosphate) binding in airway tissue membranes. Muscarinic acetylcholine receptor (mAChR)-mediated guanine nucleotide-binding regulatory protein (G protein) activation and the functional interaction between receptors and the respective G proteins were investigated using an agonist-induced [(35)S]guanosine-5'-O-(gamma-thiotriphosphate) ([(35)S]GTPgammaS)-binding approach in membranes of 3 native equine airway segments (trachea, bronchus and lung), which differ tremendously in mAChR density and subtype distribution; especially subtypes that couple negatively to adenylyl cyclase through G(i/0) proteins, i.e. M(2) receptors. The assay was initi...
Antipyrine and lidocaine are cleared faster in horses than in humans: acetaminophen may be handled similarly. The following studies were designed to evaluate plasma elimination kinetics of intravenously administered antipyrine, acetaminophen and lidocaine among 9 healthy adult horses and 9 healthy drug-free humans (3 each per drug group), in order to compare potential species differences in drug-metabolizing ability. Acetaminophen is largely biotransformed in humans by hepatic glucuronide and sulfate conjugation, whereas both antipyrine and lidocaine are oxidized by hepatic microsomal mixed-function oxidases. Thus, plasma clearances of these drugs are thought to reflect differences in hepatic oxidativ...