Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
Publisher:
Royal Society,
Frequency: Twenty four no. a year, 2008-
Country: England
Language: English
Author(s):
Royal Society (Great Britain)
Start Year:1934 -
ISSN:
0962-8436 (Print)
1471-2970 (Electronic)
0962-8436 (Linking)
1471-2970 (Electronic)
0962-8436 (Linking)
Impact Factor
6.671
2022
| NLM ID: | 7503623 |
| (OCoLC): | 01403239 |
| (DNLM): | P13080000(s) |
| Coden: | PTRBAE |
| LCCN: | 86645785 |
| Classification: | W1 PH606 |
Twenty-five thousand years of fluctuating selection on leopard complex spotting and congenital night blindness in horses. Leopard complex spotting is inherited by the incompletely dominant locus, LP, which also causes congenital stationary night blindness in homozygous horses. We investigated an associated single nucleotide polymorphism in the TRPM1 gene in 96 archaeological bones from 31 localities from Late Pleistocene (approx. 17 000 YBP) to medieval times. The first genetic evidence of LP spotting in Europe dates back to the Pleistocene. We tested for temporal changes in the LP associated allele frequency and estimated coefficients of selection by means of approximate Bayesian computation analyses. Our result...