Teratology.
Discontinued
Publisher:
Wiley-Liss. New York, NY : Wiley-Liss
Frequency: Monthly, 1988-
Country: United States
Language: English
Author(s):
Teratology Society., Wistar Institute of Anatomy and Biology.
Start Year:1968 - 2002
Identifiers
| ISSN: | 0040-3709 (Print) 0040-3709 (Linking) |
| NLM ID: | 0153257 |
| (DNLM): | T06020000(s) |
| (OCoLC): | 01767298 |
| Coden: | TJADAB |
| LCCN: | 68130668 |
| Classification: | W1 TE57G |
Teratological effects of western equine encephalitis virus on the fetal nervous system of Macaca mulatta. Fetal rhesus monkeys were inoculated intracerebrally with an attenuated strain of western equine encephalitis virus. All animals developed microcephaly. Twelve of sixteen monkeys developed ex vacuo hydrocephalus. All virus inoculated fetuses developed WEE virus antibody. Virus could not be recovered at the time of delivery. Monkeys with the highest WEE antibody titers showed the greatest degree of hydrocephalus.
Effects of influenza, mumps, and western equine encephalitis viruses on fetal rhesus monkeys (Macaca mulatta). Pregnant Rhesus monkeys were infected via instillation of influenza, mumps and western equine encephalomyelitis viruses respectively into the amniotic sacs at approximately 90 days gestation to determine if fetal infections would occur. Virus was recovered from fetal tissues after seven days in 100% of the exposed animals. Thus, the viruses are capable of causing fetal infection. Rhesus monkey fetuses were inoculated with influenza, mumps and WEE viruses by the direct intracerebral route at approximately 90 days gestation to determine possible teratogenicity of the viruses. influenza virus cau...