Toxicology and applied pharmacology.
Publisher:
Academic Press. New York, NY : Academic Press
Frequency: Semimonthly 1999-
Country: United States
Language: English
Start Year:1959 -
ISSN:
0041-008X (Print)
1096-0333 (Electronic)
0041-008X (Linking)
1096-0333 (Electronic)
0041-008X (Linking)
Impact Factor
3.8
2022
| NLM ID: | 0416575 |
| (DNLM): | T13880000(s) |
| (OCoLC): | 01695655 |
| Coden: | TXAPA9 |
| Classification: | W1 TO95 |
Equine cytochrome P450 2B6–genomic identification, expression and functional characterization with ketamine. Ketamine is an anesthetic and analgesic regularly used in veterinary patients. As ketamine is almost always administered in combination with other drugs, interactions between ketamine and other drugs bear the risk of either adverse effects or diminished efficacy. Since cytochrome P450 enzymes (CYPs) play a pivotal role in the phase I metabolism of the majority of all marketed drugs, drug-drug interactions often occur at the active site of these enzymes. CYPs have been thoroughly examined in humans and laboratory animals, but little is known about equine CYPs. The characterization of equine CYP...
Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion. Ketamine is widely used as an anesthetic in a variety of drug combinations in human and veterinary medicine. Recently, it gained new interest for use in long-term pain therapy administered in sub-anesthetic doses in humans and animals. The purpose of this study was to develop a physiologically based pharmacokinetic (PBPk) model for ketamine in ponies and to investigate the effect of low-dose ketamine infusion on the amplitude and the duration of the nociceptive withdrawal reflex (NWR). A target-controlled infusion (TCI) of ketamine with a target plasma level of 1 microg/ml S-ketamine over 120 ...
CYP3A in horse intestines. The intestinal enterocytes provide the initial site for cytochrome P450 (CYP)-mediated metabolism of orally absorbed xenobiotics. In man and some animal species, the CYP3A subfamily is highly expressed in the intestines and considered to be important in the first-pass metabolism of drugs and other xenobiotics. The aim of the present study was to investigate the mRNA expression, immunohistochemical localization and catalytic activity of CYP3A in the intestines of horse. Real-time RT-PCR analyses showed that the highest CYP3A mRNA expression was present in the duodenum with a decreasing level to...
Pharmacokinetics and pharmacodynamic effects of amiodarone in plasma of ponies after single intravenous administration. Atrial fibrillation is a well-known heart disease in horses. The common therapy consists of administration of quinidine. More potent antiarrhythmic drugs have become available for human therapy and the use of these as alternatives to quinidine for equine antiarrhythmic therapy is a matter of interest. Amiodarone (AMD) is used in human medicine for treatment of many arrhythmias, including atrial fibrillation. Its disposition in horses has not yet been investigated. The purpose of this study was to measure the effect of single intravenous doses of amiodarone (5 and 7 mg/kg) on the surface electr...
Experimental equine aflatoxicosis. Adult male Shetland ponies, two per dose level, were given aflatoxin daily at levels of 0.3, 0.15, or 0.075 mg/kg. Signs of toxicosis included inappetence, depression, tremors, and terminal prostration. Deaths occurred at 12 and 16 days (0.3 mg/kg), 25 and 32 days (0.15 mg/kg), and 36 and 39 days (0.075 mg/kg). Prothrombin time, sulfabromophthalein clearance time, total plasma bilirubin, and icteric index increased markedly before death. Elevations in plasma activity of aspartate amino transferase (AST) were observed 1 to 4 days after the start of aflatoxin administration in the high dose grou...