Toxicology mechanisms and methods.
Publisher:
Taylor and Francis,. London : Informa Healthcare
Frequency: Monthly except Jan. Apr. & Aug., Feb. 2006-
Country: England
Language: English
Start Year:2002 -
ISSN:
1537-6516 (Print)
1537-6524 (Electronic)
1537-6516 (Linking)
1537-6524 (Electronic)
1537-6516 (Linking)
Impact Factor
3.2
2022
| NLM ID: | 101134521 |
| (OCoLC): | 48251225 |
| LCCN: | 2001215311 |
| Classification: | W1 TO95BF |
The toxicokinetics of cyanide and mandelonitrile in the horse and their relevance to the mare reproductive loss syndrome. The epidemiological association between black cherry trees and mare reproductive loss syndrome has focused attention on cyanide and environmental cyanogens. This article describes the toxicokinetics of cyanide in horses and the relationships between blood cyanide concentrations and potentially adverse responses to cyanide. To identify safe and humane blood concentration limits for cyanide experiments, mares were infused with increasing doses (1-12 mg/min) of sodium cyanide for 1 h. Infusion at 12 mg/min produced clinical signs of cyanide toxicity at 38 min; these signs included increased heart...
A simple and highly sensitive spectrophotometric method for the determination of cyanide in equine blood. An epidemiological association among black cherry trees (Prunus serotina), eastern tent caterpillars (Malacosoma americana), and the spring 2001 episode of mare reproductive loss syndrome in central Kentucky focused attention on the potential role of environmental cyanogens in the causes of this syndrome. To evaluate the role of cyanide (CN (-)) in this syndrome, a simple, rapid, and highly sensitive method for determination of low parts per billion concentrations of CN (-) in equine blood and other biological fluids was developed. The analytical method is an adaptation of methods commonly in ...