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Toxicologic pathology.
Publisher:
Society of Pharmacological and Environmental Pathologists.. Thousand Oaks, Calif. : Sage Publications
Frequency: Seven no. a year, 2005-
Country: United States
Language: English
Author(s):
Society of Pharmacological and Environmental Pathologists (U.S.), Society of Toxicologic Pathologists (U.S.), Society of Toxicologic Pathology.
Start Year:1978 -
ISSN:
0192-6233 (Print)
1533-1601 (Electronic)
0192-6233 (Linking)
1533-1601 (Electronic)
0192-6233 (Linking)
Impact Factor
1.5
2023
| NLM ID: | 7905907 |
| (DNLM): | T13790000(s) |
| (OCoLC): | 05035503 |
| Coden: | TOPADD |
| LCCN: | 79643079 |
| Classification: | W1 TO892 |
The Equine Hoof: Laminitis, Progenitor (Stem) Cells, and Therapy Development. The equine hoof capsule, composed of modified epidermis and dermis, is vital for protecting the third phalanx from forces of locomotion. There are descriptions of laminitis, defined as inflammation of sensitive hoof tissues but recognized as pathologic changes with or without inflammatory mediators, in the earliest records of domesticated horses. Laminitis can range from mild to serious, and signs can be acute, chronic, or transition from acute, severe inflammation to permanently abnormal tissue. Damage within the intricate dermal and epidermal connections of the primary and secondary lamellae...
The influence of age on serum concentrations of cardiac troponin I: results in rats, monkeys, and commercial sera. Cardiac troponins serve as serum biomarkers of myocardial injury. The current study examined the influence of age on serum concentrations of cardiac troponin I (cTnI). An ultrasensitive immunoassay was used to monitor cTnI concentrations in Sprague-Dawley (SD) rats and Erythrocebus patas monkeys of different ages. The mean cTnI concentrations were highest in 10-day-old rats compared to 25-, 40-, and 80-day-old SD rats. Cardiomyocyte remodeling was apparent in hearts from 10-day-old SD rats as evident by hypercellularity, irregularly shaped nuclei, and moderate numbers of myocytes undergoing mi...
Renal toxicity of non-steroidal anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs represent the most heavily prescribed and used class of drugs in human medicine. Most are derivatives of either salicylates, propionic acid, indoleacetic acid, anthranilic acid, pyrazolone, or oxicams. They depress the synthesis of prostaglandins from arachidonic acid by reversible inhibition of the enzyme cyclooxygenase. In the kidney, prostaglandins PGE2 and PGI2 modulate the vasoconstrictor effects of angiotensin II, norepinephrine, and vasopressin. In the presence of volume contraction, anesthesia, or disease states associated with high levels of these...
